Zink hatz nukleeasak (ZFN)

Genoma edizio zehatzak norakoak nukleotido genomaren sekuentzia aldaketa da.

Azken hamarkadan DNA lotzeko proteina programagarriak garatu dira, nukleasa bat genomako edozein puntutan mozteko gidatzeko..

The Zinc Finger Nuclease (ZFN) technique uses natural proteins that bind to DNA in a sequence-specific way, fusionatutako nukleasa a gisa mozteko aukera emanez “DNA guraizea’ toki zehatz horretan.

Sistema hau osatzen dute:

• a “Zinc Finger” domain (recognising a sequence of specific base pairs triplets in the DNA sequence)
• kate bikoitzeko DNA mozten duen nukleasa

Loturak

• EFSA Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site-Directed Nucleases with similar function (2012)

Method of the Year 2011: Gene-editing nucleases – by Nature Video