Genome editing yog tus leej ntxiv yog hloov tus lawv liag nucleotide lub genome.
Dhau lub xyoo caum programmable DNA binding proteins muaj tau tsim uas yuav qhia tau ib nuclease txiav ntawm tej targeted taw tes rau hauv lub genome.
Tus Zinc ntiv tes Nuclease (ZFN) Txheej txheem siv tej proteins uas bind rau DNA hauv ib theem-specific txoj kev, Tas cov fused nuclease txiav raws li ib tug “DNA scissor’ nyob ntawd qhov chaw ntawd.
Lub kaw lus no consists ntawm:
- Ib "Zinc Finger" domain (recognising ib theem ntawm puag khub triplets hauv lub DNA sequence)
- Ib nuclease uas to thiab ob-tso tseg DNA
Kev mus
